|
|
|
|
Predicting protein crystallizability and nucleation
|
|
|
|
|
|
|
|
نویسنده
|
sánchez-puig n. ,sauter c. ,lorber b. ,giegé r. ,moreno a.
|
|
منبع
|
protein and peptide letters - 2012 - دوره : 19 - شماره : 7 - صفحه:725 -731
|
|
چکیده
|
The outcome of protein crystallization attempts is often uncertain due to inherent features of the protein or to the crystallization process that are not fully under control of the experimentalist. the aim of this contribution is to propose user-friendly tools that can increase the success rate of a protein crytallization project. different bioinformatic approaches to predict the crystallization feasibility (before any crystallization attempts are undertaken) are discussed and a novel approach to assess the nucleation process of a given protein is proposed. practical examples illustrate these two points. © 2012 bentham science publishers.
|
|
کلیدواژه
|
Crystal growth; Crystallization feasibility; Nucleation; Proteins; Surface energy; X-ray diffraction
|
|
آدرس
|
instituto de química,universidad nacional autónoma de méxico,circuito exterior,c.u.,méxico, Mexico, architecture et réactivité de l'arn,université de strasbourg,cnrs,ibmc,upr9002,15 rue rené, France, architecture et réactivité de l'arn,université de strasbourg,cnrs,ibmc,upr9002,15 rue rené, France, instituto de química,universidad nacional autónoma de méxico,circuito exterior,c.u.,méxico, Mexico, instituto de química,universidad nacional autónoma de méxico,circuito exterior,c.u.,méxico, Mexico
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|