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(Acyloxy)alkoxy moiety as amino acids protecting group for the synthesis of (R,R)-2,7 diaminosuberic acid via RCM
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نویسنده
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mollica a. ,feliciani f. ,stefanucci a. ,fadeev e.a. ,pinnen f.
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منبع
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protein and peptide letters - 2012 - دوره : 19 - شماره : 12 - صفحه:1245 -1249
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چکیده
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A new synthetic pathway is described to prepare asymmetrically protected 2,7-diaminosuberic acid. this strategy exploits (acyloxy)alkoxy promoiety as protecting group and rcm reaction using second generation grubbs catalyst and provides the trans isomer of (2r,7r)-7-(((9h-fluoren-9-yl)methoxy)carbonylamino) -2-(tert-butoxycarbonylamino)-8-methoxy-8-oxooct-4-enoic acid,which was in turn reduced to obtain (2r,7r)-7-(((9h-fluoren-9-yl)methoxy)carbonylamino)-2-(tert- butoxycarbonylamino)-8-methoxy-8-oxooctanoic acid. © 2012 bentham science publishers.
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کلیدواژه
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(acyloxy)alkoxy; Diaminosuberic acid; Grubbs catalyst; Orthogonal protecting groups; Ring closing metathesis
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آدرس
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faculty of pharmacy,department of pharmaceutical sciences,university of chieti-pescara g. d'annunzio,via dei vestini 31,66100, Italy, faculty of pharmacy,department of pharmaceutical sciences,university of chieti-pescara g. d'annunzio,via dei vestini 31,66100, Italy, dipartimento di chimica,università degli studi di roma la sapienza,p.le aldo moro 5, Italy, department of chemistry,university of california irvine,1212 natural sciences building 1,irvine, United States, faculty of pharmacy,department of pharmaceutical sciences,university of chieti-pescara g. d'annunzio,via dei vestini 31,66100, Italy
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Authors
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