|
|
|
|
Synergistic enhancement of cancer therapy using a combination of fusion protein MG7-scFv/SEB and tumor necrosis factor alpha
|
|
|
|
|
|
|
|
نویسنده
|
lu x. ,cheng c. ,wang g. ,shu x. ,ma j. ,tong q.
|
|
منبع
|
protein and peptide letters - 2013 - دوره : 20 - شماره : 4 - صفحه:467 -472
|
|
چکیده
|
The fusion protein mg7-scfv/seb has shown anti-tumor activity on gastric cancer in vitro and in vivo. tumor necrosis factor-alpha (tnf-α) is a cytokine exerting anti-tumor effectiveness in various models and modes of applications. in this study,we explored the combination effects of mg7-scfv/seb and tnf-α in experimental gastric cancer. both mg7-scfv/seb and tnf-α could effectively result in a significant inhibition of tumor growth in our experimental models when administered alone. whats more,mg7-scfv/seb synergized with tnf-α in further reducing the growth of gastric tumors in gastric-tumor-bearing rats as compared to mono therapy. additionally,the survival rate of gastric-tumorbearing rats administrated with combined therapy was significantly higher than that of rats treated with mg7-scfv/seb or tnf-α. these results indicate that combined therapy with mg7-scfv/seb and tnf-α is a promising strategy for human cancer therapy. © 2013 bentham science publishers.
|
|
کلیدواژه
|
Combination; Gastric cancer; Mg7-scfv/seb; Superantigens; Tumor necrosis factor
|
|
آدرس
|
department of gastrointestinal surgery,tongji medical college,huazhong university of science and technology,1277 jiefang avenue,wuhan, China, department of gastrointestinal surgery,tongji medical college,huazhong university of science and technology,1277 jiefang avenue,wuhan, China, department of gastrointestinal surgery,tongji medical college,huazhong university of science and technology,1277 jiefang avenue,wuhan, China, department of gastrointestinal surgery,tongji medical college,huazhong university of science and technology,1277 jiefang avenue,wuhan, China, department of gastrointestinal surgery,tongji medical college,huazhong university of science and technology,1277 jiefang avenue,wuhan, China, department of gastrointestinal surgery,tongji medical college,huazhong university of science and technology,1277 jiefang avenue,wuhan, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|