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LGnRH-III - A promising candidate for anticancer drug development
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نویسنده
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manea m. ,gbor m.
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منبع
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protein and peptide letters - 2013 - دوره : 20 - شماره : 4 - صفحه:439 -449
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چکیده
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Lamprey gonadotropin-releasing hormone-iii (lgnrh-iii; glp-his-trp-ser-his- asp-trp-lys-pro-gly-nh2),a native isoform of human gnrh (gnrh-i),was initially isolated from the brain of the sea lamprey (petromyzon marinus). it is a weak gnrh agonist,which exerts a direct antiproliferative effect on cancer cells and has an insignificant lh and fsh releasing potency in mammals. these features reveal the advantages of lgnrh-iii and its derivatives for use in cancer therapy. here we give an overview of various strategies to increase the antitumor activity of lgnrh-iii,such as amino acid replacement,cyclization,dimerization and conjugation to polymers or to chemotherapeutic agents. in vitro and in vivo antitumor activity of lgnrh-iii based compounds was demonstrated both on hormone dependent and independent tumors. © 2013 bentham science publishers.
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کلیدواژه
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Anthracyclines; Anticancer activity; Lamprey gonadotropin-releasing hormone-iii (lgnrh-iii); Peptide dimers drug - peptide conjugates; Targeted cancer chemotherapy
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آدرس
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laboratory of analytical chemistry and biopolymer structure analysis,department of chemistry,university of konstanz,78457 konstanz,germany,zukunftskolleg,university of konstanz, Germany, research group of peptide chemistry,hungarian academy of sciences,etvs lornd university,pzmny p. stny. 1/a, Hungary
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Authors
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