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Precursor mass dependent filtering of mass spectra for proteomics analysis
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نویسنده
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reiz b. ,myers m.p. ,pongor s. ,kertész-farkas a.
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منبع
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protein and peptide letters - 2014 - دوره : 21 - شماره : 8 - صفحه:858 -863
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چکیده
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Identification and elimination of noise peaks in mass spectra from large proteomics data streams simultaneously improves the accuracy of peptide identification and significantly decreases the size of the data. there are a number of peak filtering strategies that can achieve this goal. here we present a simple algorithm wherein the number of highest intensity peaks retained for further analysis is proportional to the mass of the precursor ion. we show that this technique provides an improvement over other intensity based strategies,especially for low mass precursors. © 2014 bentham science publishers.
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کلیدواژه
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LC-MS/MS; Mass spectrometry; Noise filtering; Peak filtering; Proteomics
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آدرس
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international centre for genetic engineering and biotechnology,34012 trieste,italy,biological research centre,szeged temesvárikrt 67, Hungary, international centre for genetic engineering and biotechnology, Italy, international centre for genetic engineering and biotechnology,34012 trieste,italy,faculty of information technology,pázmánypéter catholic university, Hungary, international centre for genetic engineering and biotechnology, Italy
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Authors
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