Ubiquitin carboxyl hydrolase l1 significance for human diseases

Ubiquitin carboxyl hydrolase l1 (uch-l1) is an abundant multifunctional neuron protein. it plays an important role in maintaining the ubiquitin proteasome system (ups),vital for recognizing and degrading dysfunctional proteins in organisms. in recent decades,uch-l1 has been implicated in the pathogenesis of many diseases,including neurodegenerative disorders,cancer and diabetes. however,the mechanisms of uch-l1 involvement have yet to be revealed in detail. since uch-l1 contributes many different functions to cell metabolism,its role and regulation might be more complex than previously thought and it has become a research target in many laboratories. in this review,we summarize recent findings related to the actions of uch-l1 in several human diseases. © 2014 bentham science publishers.