Apolipoprotein e derived peptides inhibit the pro-inflammatory effect of lysophosphatidylcholine

Apolipoprotein-derived peptides have emerged as a potential candidate for the treatment of various inflammatory disease conditions. these peptides bind to pro-inflammatory lipids and inhibit their inflammatory functions. lysophosphatidylcholine (lpc) is a potent pro-inflammatory lipid and increased level of circulating lpc plays a major role in various acute and chronic inflammatory conditions. in this report we examined the effect of peptides derived from the c-terminal domain of human apolipoprotein e on the properties of lpc. our results show that the peptides (e8,e10 and e11) bind to lpc and inhibit lpc-induced up-regulation of pro-inflammatory markers in human leukocytes. the results suggest that these peptides can be used as an anti-inflammatory agent in inflammatory conditions in which increased level of lpc is a culprit. © 2014 bentham science publishers.