|
|
|
|
Analgesic effects of huwentoxin-IV on animal models of inflammatory and neuropathic pain
|
|
|
|
|
|
|
|
نویسنده
|
liu y. ,wu z. ,tang d. ,xun x. ,liu l. ,li x. ,nie d. ,xiang y. ,yii j. ,yi j.
|
|
منبع
|
protein and peptide letters - 2014 - دوره : 21 - شماره : 2 - صفحه:153 -158
|
|
چکیده
|
Huwentoxin-iv (hwtx-iv),a peptide with 35 amino acid residues,was discovered in the venom of spider ornithoctonus huwena. the peptide had an inhibitory effect on a tetrodotoxin-sensitive (ttx-s) sodium channel with highly sensitive to nav1.7,an attractive target for pain release therapy. in this study we further demonstrated the analgesic effects of hwtx-iv using mouse and rat as an inflammatory pain model and/or a neuropathic pain models. in the both cases,the analgesic effects of the peptide were dose-dependent,and statistically significant. in the inflammatory model,100 μg/kg of hwtx-iv produced an efficient reversal of hyperalgesia up to 63.6% after injection of formalin in rats with the efficiency equivalent to that of morphine at 50 μg/kg,and 200 μg/kg of hwtx-iv produced protective effect up to 55.6% after injection of acetic acid with the efficiency equivalent to that of morphine at 100 μg/kg. in the spinal nerve model,the peptide produced the longer and higher reversal effect on allodynia than mexiletine. these results demonstrated that hwtx-iv released efficiently the acute inflammatory pain and chronic neuropathic pain in these animals,suggesting that hwtx-iv was a potential and efficient candidate for further clinical drug development against inflammatory and neuropathic pain. © 2014 bentham science publishers.
|
|
کلیدواژه
|
Analgesic; Huwentoxin-IV; Inflammatory pain; Neuropathic pain; Neurotoxin
|
|
آدرس
|
college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China, college of chemistry and chemical engineering,hunan institute of science and technology,yueyang, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|