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Cell penetrating peptides as a therapeutic strategy in chronic lymphocytic leukemia
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نویسنده
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arrouss i. ,decaudin d. ,choquet s. ,azar n. ,parizot c. ,zini j.m. ,nemati f. ,rebollo a.
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منبع
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protein and peptide letters - 2015 - دوره : 22 - شماره : 6 - صفحه:539 -546
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چکیده
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Pp2a is a serine/threonine phosphatase critical to a number of physiological and developmental processes. in this manuscript,we show that a peptide,specifically blocking the caspase-9/pp2a interaction,dpt-c9h,induces apoptosis in primary tumour b cells isolated from peripheral blood mononuclear cells or bone marrow of chronic lymphocytic leukemia (cll) patients,but not on b cells obtained from healthy donors (hd). moreover,in both cll patients and hd,dpt-c9h does not induce apoptosis on t-and nkcells and monocytes. our results strongly suggest that dpt-c9h peptide has tumour specificity and that caspase-9/pp2ac interaction constitutes a novel therapeutic approach for the treatment in cll patients. © 2015 bentham science publishers.
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کلیدواژه
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Apoptosis; Caspase-9; CLL; Penetrating peptides; PP2A
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آدرس
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inserm umrs 945,83,université pierre et marie curie,91 bd de l'hôpital,paris, Morocco, department of medical hematology,institut curie,paris,france,laboratory of preclinical investigation,translational research department,institut curie, France, hôpital pitié salpêtrière,service d'hématologie clinique, France, hôpital pitié salpêtrière,service d'hématologie clinique, France, ap-hp,hôpital pitié salpêtrière,département d'immunologie cellulaire et tissulaire, France, ap-hp hôpital saint louis,service d'hématologie, France, laboratory of preclinical investigation,translational research department,institut curie, France, inserm umrs 945,83,université pierre et marie curie,91 bd de l'hôpital, France
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Authors
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