An overview of interleukin-17A and interleukin-17 receptor A structure,interaction and signaling

Interleukin-17a (il-17a) and its receptor (il-17ra) are prototype members of il-17 ligand/receptor family firstly identified in cd4+ t cells,which comprises six ligands (il-17a to il-17f) and five receptors (il-17ra to il-17re). il-17a is predominantly secreted by t helper 17 (th17) cells,and plays important roles in the development of autoimmune and inflammatory diseases. il-17ra is widely expressed,and forms a complex with il-17rc. binding of il-17a to this receptor complex triggers the activation of several intracellular signaling pathways. in this review,we aimed to summarize literature data about molecular features of il-17a and il-17ra from gene to mature protein. we are also providing insight into regulatory mechanisms,protein structural conformation,including ligand-receptor interaction,and an overview of signaling pathways. our aim was to compile the data on molecular characteristics of il-17a and il-17ra which may help in the understanding of their functions in health and disease. © 2015 bentham science publishers.