Prevention of serum albumin glycation/fibrillation by β-cyclodextrin functionalized magnetic nanoparticles

Nowadays,glycation induced protein aggregation and related opposing strategies have received much attention. we present the effect of functionalized magnetic core-shell nanoparticles of fe3o4 (mnps) with β-cyclodextrin (β-cd) on the aggregation/fibrillation of bovine serum albumin (bsa) under diabetic condition known as amyloidogenesis. to confirm the β-cd conjugation on mnp,fourier transform infrared spectroscopy (ftir),x-ray diffraction (xrd),thermogravimetric analysis (tga),transmission electron microscopy (tem) and vibrating sample magnetometer (vsm) methods were applied. moreover,spectrofluorimetry and spectropolarimetry were utilized to analyze the effect of β-cd/fe3o4 mnps on the aggregation and amyloidogenesis of bsa through glycation. the bsa amyloidogenesis was significantly inhibited by interfering β-cd-mnps that may present the possible diagnostic and preventive applications against the degenerative effects of protein glycation/fibrillation under diabetes. © 2015 bentham science publishers.