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Intrinsic disorder-based design of stabilizing disulphide bridge in Gαo protein
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نویسنده
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nagibina g.s. ,tin u.f. ,glukhov a.s. ,melnik t.n. ,melnik b.s.
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منبع
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protein and peptide letters - 2016 - دوره : 23 - شماره : 2 - صفحه:176 -184
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چکیده
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In this study,we have used an approach that allows us to determine in what region of the polypeptide chain of protein it is required to insert a disulphide bond in order to stabilize it. in our previous paper [melnik et al.,jbsd. 2012] it was proposed that to search for a weak site in the protein,it is possible to use programs (for example,pondr-fit and isunstruct) finding intrinsic disorder protein regions. we suggested that in structured globular proteins,such programs predict not protein regions in the polypeptide chain disordered under native conditions,but weakened
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کلیدواژه
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feebly stabilized ones. Accordingly
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آدرس
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institute of protein research,russian academy of sciences,vavilova street 34,pushchino,moscow region, Russian Federation, institute of protein research,russian academy of sciences,vavilova street 34,pushchino,moscow region, Russian Federation, institute of protein research,russian academy of sciences,vavilova street 34,pushchino,moscow region, Russian Federation, institute of protein research,russian academy of sciences,vavilova street 34,pushchino,moscow region, Russian Federation, institute of protein research,russian academy of sciences,vavilova street 34,pushchino,moscow region, Russian Federation
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Authors
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