|
|
|
|
Identification of SER-PRO-CYS peptide in blood serum of multiple sclerosis patients
|
|
|
|
|
|
|
|
نویسنده
|
myronovkij s. ,negrych n. ,nehrych t. ,tkachenko v. ,souchelnytskyi s. ,stoika r. ,kit y.
|
|
منبع
|
protein and peptide letters - 2016 - دوره : 23 - شماره : 9 - صفحه:808 -811
|
|
چکیده
|
Monitoring of multiple sclerosis (ms) requires additional molecular markers. recently,we used original tca-precipitation/extraction approach in combination with maldi tof/tof mass-spectrometry and identified earlier unknown 48 kda form of the unconventional myosin ic isoform b (myo1c) in blood serum of the ms patients. further examination of tca-extracted fraction of blood serum of these patients by means of thin-layer chromatography and hplc gel-filtration allowed detecting 300-500 da peptides. maldi tof/tof massspectrometry of these peptides showed that they contain ser-pro-cys amino acid sequence. we discussed potential mechanisms of a release of these peptides that were earlier unknown in blood serum of the ms patients. © 2016 bentham science publishers.
|
|
کلیدواژه
|
Blood serum; Multiple sclerosis; Peptides
|
|
آدرس
|
department of regulation of cells proliferation and apoptosis,institute of cell biology,national academy of sciences of ukraine,drahomanov st.,14/16,lviv, Ukraine, department of neurology,danylo halytsky lviv national medical university,lviv, Ukraine, department of neurology,danylo halytsky lviv national medical university,lviv, Ukraine, department of regulation of cells proliferation and apoptosis,institute of cell biology,national academy of sciences of ukraine,drahomanov st.,14/16,lviv, Ukraine, center for translational molecular medicine,college of medicine,qatar university,doha,qatar,oranta cancer diagnostics ab,uppsala, Sweden, department of regulation of cells proliferation and apoptosis,institute of cell biology,national academy of sciences of ukraine,drahomanov st.,14/16,lviv, Ukraine, department of regulation of cells proliferation and apoptosis,institute of cell biology,national academy of sciences of ukraine,drahomanov st.,14/16,lviv, Ukraine
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|