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α-Lactalbumin: of camels and cows
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نویسنده
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redington j.m. ,breydo l. ,almehdar h.a. ,redwan e.m. ,uversky v.n.
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منبع
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protein and peptide letters - 2016 - دوره : 23 - شماره : 12 - صفحه:1072 -1080
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چکیده
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Since camel milk has been attributed with various medicinal properties not found in bovine milk,we are systematically examining the differences between different proteins in bovine and camel milk. the purpose of this study is to investigate the structural differences between the bovine and camel α- lactalbumins. α-lactalbumin is a highly abundant protein present in the milk of all mammalian species. here we found several structural differences between bovine and camel α-lactalbumins: camel protein is more stable towards thermal and phmediated denaturation but less stable towards guanidine hydrochloride-mediated unfolding,aggregates faster and is predicted to be more disordered than bovine α- lactalbumin. © 2016 bentham science publishers.
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کلیدواژه
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Aggregation; CD; Fluorescence; Guanidine hydrochloride-mediated unfolding; Intrinsically disordered protein; α-lactalbumin
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آدرس
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usf health byrd alzheimer's research institute,department of molecular medicine,morsani college of medicine,university of south florida,12901 bruce b. downs blvd.,mdc07,tampa,fl, United States, usf health byrd alzheimer's research institute,department of molecular medicine,morsani college of medicine,university of south florida,12901 bruce b. downs blvd.,mdc07,tampa,fl, United States, department of biological science,faculty of science,king abdulaziz university,jeddah,po box 80203,jeddah, Saudi Arabia, department of biological science,faculty of science,king abdulaziz university,jeddah,po box 80203,jeddah,saudi arabia,protective and therapeutic proteins laboratory,protein research department,genetic engineering and biotechnology research institute gebri,city for scientific research and technology applications,new borg el arab,alexandria, Egypt, usf health byrd alzheimer's research institute,department of molecular medicine,morsani college of medicine,university of south florida,12901 bruce b. downs blvd.,mdc07,tampa,fl,united states,department of biological science,faculty of science,king abdulaziz university,jeddah,po box 80203,jeddah,saudi arabia,laboratory of structural dynamics,stability and folding of proteins,institute of cytology,russian academy of sciences,st. petersburg, Russian Federation
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Authors
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