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Dihydromyricetin reduces TGF-β via P53 activation-dependent mechanism in hepatocellular carcinoma HepG2 cells
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نویسنده
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huang x. ,lian t. ,guan x. ,liu b. ,hao s. ,zhang j. ,bao s. ,tan x. ,zhu r.
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منبع
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protein and peptide letters - 2017 - دوره : 24 - شماره : 5 - صفحه:419 -424
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چکیده
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Natural antineoplastic drug development is crucial to treatment of clinical oncology. dihydromyricetin,a bioactive flavonoid compound was extracted from the stems and leaves of ampelopsis grossedentata. it exhibited anticancer activity and induced apoptosis in human hepatocellular carcinoma cells according to our previous studies. in this study,we demonstrated that dhm could significantly inhibit proliferation and induce apoptosis in hepg2 cells with mtt and flow cytometry methods. it is very interesting that we found dhm could regulate tgf-β signal pathway and which has a crosstalk with p53,smad3 and p-smad2/3 proteins. meanwhile,we confirmed that dhm showed antitumor activity by regulating the activation of the p53-dependent pathways (mdm2,p-mdm2,bax and bcl-2). these findings defined and supported a novel mechanism that dhm could induce cell apoptosis by reducing tgf-β via p53 signal pathway in hepg2 cells. © 2017 bentham science publishers.
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کلیدواژه
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Anti-cancer; Apoptosis; Dihydromyricetin; Hepatocellular carcinoma; P53; Proliferation
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آدرس
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laboratory of hepatobiliary surgery,guangdong medical university,zhanjiang,china,zhanjiang key laboratory of hepatobiliary disease,guangdong medical university,zhanjiang, China, laboratory of hepatobiliary surgery,guangdong medical university,zhanjiang,china,zhanjiang key laboratory of hepatobiliary disease,guangdong medical university,zhanjiang, China, dalian medical university,9 west section,lvshun south road,dalian,china,southern medical university,guangzhou, China, laboratory of hepatobiliary surgery,guangdong medical university,zhanjiang,china,zhanjiang key laboratory of hepatobiliary disease,guangdong medical university,zhanjiang,china,pharmacy college,jinan university,guangzhou, China, laboratory of hepatobiliary surgery,guangdong medical university,zhanjiang,china,zhanjiang key laboratory of hepatobiliary disease,guangdong medical university,zhanjiang, China, clinical research center,guangdong medical university,zhanjiang, China, laboratory of hepatobiliary surgery,guangdong medical university,zhanjiang,china,zhanjiang key laboratory of hepatobiliary disease,guangdong medical university,zhanjiang, China, laboratory of hepatobiliary surgery,guangdong medical university,zhanjiang,china,zhanjiang key laboratory of hepatobiliary disease,guangdong medical university,zhanjiang, China, laboratory of hepatobiliary surgery,guangdong medical university,zhanjiang,china,zhanjiang key laboratory of hepatobiliary disease,guangdong medical university,zhanjiang, China
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Authors
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