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Diosmetin induces cell apoptosis by regulating CYP1A1/CYP1A2 due to p53 activation in HepG2 cells
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نویسنده
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liu b. ,jia k. ,yang y. ,hao s. ,lu c. ,xu f. ,feng d. ,zhu r.
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منبع
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protein and peptide letters - 2017 - دوره : 24 - شماره : 5 - صفحه:406 -412
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چکیده
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It was explored that cyp1 family of cytochromes p450 were over-expressed in several types of cancer. our study aimed to characterize anti-proliferative activity and metabolism of the natural flavonoid diosmetin in the human hepatoma cell hepg2,expressing cyp1 family. dios-induced cell apoptosis could be reversed due to p53 blockade and the cellular p53 and cyp1a1/cyp1a2 proteins levels were examined. p53 and cyp1a1/cyp1a2 proteins were upregulated by dios; when pft-α was added into cells,the p53 levels were down-regulated accompanied with up-regulated cyp1a1/cyp1a2. meanwhile,when cells were co-treated with dios and pft-α,p53 was down-regulated and cyp1a1/cyp1a2 up-regulated controlled with that of dios treated cells. the data reveal the new evidence that cytochrome p450 cyp1a regulation by p53 enzyme plays an important role in diosmetin anti-cancer activity of hepg2 cells. © 2017 bentham science publishers.
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کلیدواژه
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Apoptosis; CYP1A1/CYP1A2; Diosmetin; HepG2; P53; PFT-α
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آدرس
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laboratory of hepatobiliary surgery,zhanjiang key laboratory of hepatobiliary diseases,guangdong medical university,zhanjiang,china,pharmacy college,jinan university,guangzhou,guangdong province, China, laboratory of hepatobiliary surgery,zhanjiang key laboratory of hepatobiliary diseases,guangdong medical university,zhanjiang, China, elderly medical center,guangdong medical university,zhanjiang,guangdong province, China, laboratory of hepatobiliary surgery,zhanjiang key laboratory of hepatobiliary diseases,guangdong medical university,zhanjiang, China, laboratory of hepatobiliary surgery,zhanjiang key laboratory of hepatobiliary diseases,guangdong medical university,zhanjiang, China, pediatrics,guangdong medical university,zhanjiang,guangdong province, China, elderly medical center,guangdong medical university,zhanjiang,guangdong province, China, laboratory of hepatobiliary surgery,zhanjiang key laboratory of hepatobiliary diseases,guangdong medical university,zhanjiang, China
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Authors
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