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Renin-angiotensin system in diabetes
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نویسنده
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rein j. ,bader m.
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منبع
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protein and peptide letters - 2017 - دوره : 24 - شماره : 9 - صفحه:833 -840
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چکیده
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The renin-angiotensin system (ras) has two different axes,the classical one with the effector peptide angiotensin ii and the new one with the effector peptide angiotensin (1-7). both peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences,nephropathy,retinopathy and cardiomyopathy in animal models and patients. in diabetes,angiotensin ii acts mostly deleterious and angiotensin (1-7) protective. in this review we summarize the knowledge about the role of the different ras axes in diabetes mellitus and the use of drugs interfering with the ras in the therapy of the disease.
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کلیدواژه
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Diabetes mellitus; Drugs; Effector peptide angiotensin; Pathogenesis; Renin-angiotensin system; Therapy
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آدرس
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charité - university medicine berlin, Germany, charité - university medicine berlin,germany,max delbrück center for molecular medicine,robert-rössle-str. 10,berlin,germany,german center for cardiovascular research (dzhk),berlin site,berlin,germany,berlin institute of health (bih),berlin,germany,institute for biology,university of lübeck,lübeck, Germany
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Authors
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