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Angiotensin-converting enzymes (ACE and ACE2) as potential targets for malignant epithelial neoplasia: Review and bioinformatics analyses focused in oral squamous cell carcinoma
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نویسنده
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de carvalho fraga c.a. ,farias l.c. ,jones k.m. ,de paula a.m.b. ,guimarães a.l.s.
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منبع
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protein and peptide letters - 2017 - دوره : 24 - شماره : 9 - صفحه:784 -792
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چکیده
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Introduction: the renin-angiotensin system (ras) has emerged as being related to vascular disease. recently the ras has been associated with obesity,diabetes,and even cancer. objective: this review and bioinformatics analyses focuses on the investigation of angiotensinconverting enzymes (ace and ace2) as therapeutical targets for malignant epithelial neoplasia,specifically for oral squamous cell carcinoma (oscc). conclusion: the literature review and bioinformatics analyses showed that ace and ace2 are interesting targets for oscc treatment. studies involving ras and oscc should be encouraged for experimental validation. © 2017 bentham science publishers.
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کلیدواژه
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ACE; Ang 1-7; Angiogenesis; Angiotensin-converting enzyme; Head and neck cancer; Obesity
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آدرس
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department of medicine,universidade federal de alagoas,arapiraca,alagoas, Brazil, department of dentistry,universidade estadual de montes claros,hospital universitário clemente faria,laboratório de pesquisa em saúde,562 av. cula mangabeira santo expedito,minas gerais,mg, Brazil, dean of research,única educacional,montes claros,minas gerais, Brazil, department of dentistry,universidade estadual de montes claros,hospital universitário clemente faria,laboratório de pesquisa em saúde,562 av. cula mangabeira santo expedito,minas gerais,mg, Brazil, department of dentistry,universidade estadual de montes claros,hospital universitário clemente faria,laboratório de pesquisa em saúde,562 av. cula mangabeira santo expedito,minas gerais,mg, Brazil
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Authors
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