Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats

Background: sleeve gastrectomy (sg) has been used as a multipurpose surgical procedure for the treatment of obesity. objectives: the present study aimed to assess the effects of sg on the metabolic and inflammatory profile and renin-angiotensin system (ras) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. methods: male wistar rats were treated with a standard diet or high-fat diet and submitted to sg or sham surgery. the glycemic and lipid profiles and gene expression of inflammatory markers and ras components in adipose tissue were evaluated. results: sg led to weight loss,decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05),c-peptide (p < 0.05),insulin (p < 0.001) and total cholesterol (p < 0.05) levels. in addition,sg led to a decrease in the expression of tumor necrosis factor-alpha (tnf-α) (p < 0.01),interleukin- 6 (il-6) (p < 0.001),angiotensinogen (agt) (p < 0.001) and angiotensin converting enzyme (ace) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ace2) (p < 0.05) in white adipose tissue. no statistically significant differences were observed for at1 (p = 0.10) and mas (p = 0.22) receptors. conclusion: this study showed that sg leads to weight loss and improves metabolic parameters. changes in the expression of ras components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the sg. © 2017 bentham science publishers.