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Where Have All the Rodents Gone? the Effects of Attrition in Experimental Research on Cancer and Stroke
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نویسنده
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holman c. ,piper s.k. ,grittner u. ,diamantaras a.a. ,kimmelman j. ,siegerink b. ,dirnagl u.
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منبع
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plos biology - 2016 - دوره : 14 - شماره : 1
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چکیده
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Given small sample sizes,loss of animals in preclinical experiments can dramatically alter results. however,effects of attrition on distortion of results are unknown. we used a simulation study to analyze the effects of random and biased attrition. as expected,random loss of samples decreased statistical power,but biased removal,including that of outliers,dramatically increased probability of false positive results. next,we performed a meta-analysis of animal reporting and attrition in stroke and cancer. most papers did not adequately report attrition,and extrapolating from the results of the simulation data,we suggest that their effect sizes were likely overestimated. © 2016 holman et al.
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آدرس
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medical neurosciences program,charité universitätsmedizin berlin,berlin, Germany, neurocure clinical research center,charité universitätsmedizin berlin,berlin,germany,center for stroke research,charité universitätsmedizin berlin,berlin, Germany, center for stroke research,charité universitätsmedizin berlin,berlin,germany,department for biostatistics and clinical epidemiology,charité universitätsmedizin berlin,berlin, Germany, medical neurosciences program,charité universitätsmedizin berlin,berlin, Germany, biomedical ethics unit,mcgill university,montréal, Canada, center for stroke research,charité universitätsmedizin berlin,berlin, Germany, neurocure clinical research center,charité universitätsmedizin berlin,berlin,germany,center for stroke research,charité universitätsmedizin berlin,berlin,germany,department of experimental neurology,charité universitätsmedizin berlin,berlin,germany,german center for neurodegenerative diseases (dzne),berlin,germany,berlin institute of health,berlin, Germany
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Authors
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