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Lef1-dependent hypothalamic neurogenesis inhibits anxiety
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نویسنده
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xie y. ,kaufmann d. ,moulton m.j. ,panahi s. ,gaynes j.a. ,watters h.n. ,zhou d. ,xue h.-h. ,fung c.m. ,levine e.m. ,letsou a. ,brennan k.c. ,dorsky r.i.
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منبع
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plos biology - 2017 - دوره : 15 - شماره : 8
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چکیده
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While innate behaviors are conserved throughout the animal kingdom,it is unknown whether common signaling pathways regulate the development of neuronal populations mediating these behaviors in diverse organisms. here,we demonstrate that the wnt/ß-catenin effector lef1 is required for the differentiation of anxiolytic hypothalamic neurons in zebrafish and mice,although the identity of lef1-dependent genes and neurons differ between these 2 species. we further show that zebrafish and drosophila have common lef1-dependent gene expression in their respective neuroendocrine organs,consistent with a conserved pathway that has diverged in the mouse. finally,orthologs of lef1-dependent genes from both zebrafish and mouse show highly correlated hypothalamic expression in marmosets and humans,suggesting co-regulation of 2 parallel anxiolytic pathways in primates. these findings demonstrate that during evolution,a transcription factor can act through multiple mechanisms to generate a common behavioral output,and that lef1 regulates circuit development that is fundamentally important for mediating anxiety in a wide variety of animal species. © 2017 xie et al.
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آدرس
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department of neurobiology and anatomy,university of utah,salt lake city,ut,united states,department of neuroscience,mahoney institute for neurosciences,perelman school for medicine,university of pennsylvania,philadelphia,pa, United States, department of neurology,university of utah,salt lake city,ut, United States, department of human genetics,university of utah,salt lake city,ut, United States, department of neurobiology and anatomy,university of utah,salt lake city,ut, United States, department of neurobiology and anatomy,university of utah,salt lake city,ut, United States, department of neurobiology and anatomy,university of utah,salt lake city,ut, United States, department of neurobiology and anatomy,university of utah,salt lake city,ut,united states,school of life sciences,peking university,beijing, China, department of microbiology,carver college of medicine,university of iowa,iowa city,ia, United States, division of neonatology,department of pediatrics,university of utah school of medicine,salt lake city,ut, United States, department of ophthalmology and visual sciences,john a. moran eye center,university of utah,salt lake city,ut,united states,department of ophthalmology and visual sciences,vanderbilt university school of medicine,nashville,tn, United States, department of human genetics,university of utah,salt lake city,ut, United States, department of neurology,university of utah,salt lake city,ut, United States, department of neurobiology and anatomy,university of utah,salt lake city,ut, United States
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Authors
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