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Arabidopsis choline transporter-like 1 (CTL1) regulates secretory trafficking of auxin transporters to control seedling growth
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نویسنده
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wang y. ,yang l. ,tang y. ,tang r. ,jing y. ,zhang c. ,zhang b. ,li x. ,cui y. ,zhang c. ,shi j. ,zhao f. ,lan w. ,luan s.
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منبع
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plos biology - 2017 - دوره : 15 - شماره : 12
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چکیده
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Auxin controls a myriad of plant developmental processes and plant response to environmental conditions. precise trafficking of auxin transporters is essential for auxin homeostasis in plants. here,we report characterization of arabidopsis ctl1,which controls seedling growth and apical hook development by regulating intracellular trafficking of pin-type auxin transporters. the ctl1 gene encodes a choline transporter-like protein with an expression pattern highly correlated with auxin distribution and is enriched in shoot and root apical meristems,lateral root primordia,the vascular system,and the concave side of the apical hook. the choline transporter-like 1 (ctl1) protein is localized to the trans-golgi network (tgn),prevacuolar compartment (pvc),and plasma membrane (pm). disruption of ctl1 gene expression alters the trafficking of 2 auxin efflux transporters—arabidopsis pm-located auxin efflux transporter pin-formed 1 (pin1) and arabidopsis pm-located auxin efflux transporter pin-formed 3 (pin3)—to the pm,thereby affecting auxin distribution and plant growth and development. we further found that phospholipids,sphingolipids,and other membrane lipids were significantly altered in the ctl1 mutant,linking ctl1 function to lipid homeostasis. we propose that ctl1 regulates protein sorting from the tgn to the pm through its function in lipid homeostasis. © 2017 wang et al.
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آدرس
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state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing,china,department of plant and microbial biology,university of california,berkeley,berkeley,ca,united states,college of life sciences,northwest university,xian,shanxi, China, state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing, China, state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing, China, department of plant and microbial biology,university of california,berkeley,berkeley,ca, United States, state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing, China, state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing, China, state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing, China, key laboratory for genetics and breeding of forest trees and ornamental plants,ministry of education,college of biological sciences and technology,beijing forestry university,beijing, China, key laboratory for genetics and breeding of forest trees and ornamental plants,ministry of education,college of biological sciences and technology,beijing forestry university,beijing, China, department of botany and plant pathology,purdue university,west lafayette,in, United States, nanjing university–nanjing forestry university joint institute for plant molecular biology,key laboratory of forest genetics and biotechnology,nanjing forestry university,nanjing, China, state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing, China, state key laboratory for pharmaceutical biotechnology,nanjing university-nanjing forestry university joint institute for plant molecular biology,college of life sciences,nanjing university,nanjing, China, department of plant and microbial biology,university of california,berkeley,berkeley,ca, United States
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Authors
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