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A20-Deficient Mast Cells Exacerbate Inflammatory Responses in Vivo
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نویسنده
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heger k. ,fierens k. ,vahl j.c. ,aszodi a. ,peschke k. ,schenten d. ,hammad h. ,beyaert r. ,saur d. ,van loo g. ,roers a. ,lambrecht b.n. ,kool m. ,schmidt-supprian m.
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منبع
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plos biology - 2014 - دوره : 12 - شماره : 1
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چکیده
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Mast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. however,this notion based on studies in mast cell-deficient mice is controversial. we therefore established an in vivo model for hyperactive mast cells by specifically ablating the nf-κb negative feedback regulator a20. while a20 deficiency did not affect mast cell degranulation,it resulted in amplified pro-inflammatory responses downstream of ige/fcεri,tlrs,il-1r,and il-33r. as a consequence house dust mite- and il-33-driven lung inflammation,late phase cutaneous anaphylaxis,and collagen-induced arthritis were aggravated,in contrast to experimental autoimmune encephalomyelitis and immediate anaphylaxis. our results provide in vivo evidence that hyperactive mast cells can exacerbate inflammatory disorders and define diseases that might benefit from therapeutic intervention with mast cell function. © 2014 heger et al.
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آدرس
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molecular immunology and signal transduction,max planck institute of biochemistry,martinsried, Germany, laboratory of immunoregulation,department of pulmonary medicine,university hospital ghent,ghent,belgium,department for molecular biomedical research,vlaams instituut voor biotechnologie,ghent, Belgium, molecular immunology and signal transduction,max planck institute of biochemistry,martinsried, Germany, department of surgery,ludwig maximilians universität,munich, Germany, institute for immunology,technische universität dresden,dresden, Germany, department of immunobiology,yale university school of medicine,new haven,ct, United States, laboratory of immunoregulation,department of pulmonary medicine,university hospital ghent,ghent,belgium,department for molecular biomedical research,vlaams instituut voor biotechnologie,ghent, Belgium, department for molecular biomedical research,vlaams instituut voor biotechnologie,ghent,belgium,department of biomedical molecular biology,ghent university,ghent, Belgium, ii. medizinische klinik,klinikum rechts der isar,technische universität münchen,munich, Germany, department for molecular biomedical research,vlaams instituut voor biotechnologie,ghent,belgium,department of biomedical molecular biology,ghent university,ghent, Belgium, institute for immunology,technische universität dresden,dresden, Germany, laboratory of immunoregulation,department of pulmonary medicine,university hospital ghent,ghent,belgium,department for molecular biomedical research,vlaams instituut voor biotechnologie,ghent,belgium,department of pulmonary medicine,erasmus university medical center,rotterdam, Netherlands, laboratory of immunoregulation,department of pulmonary medicine,university hospital ghent,ghent,belgium,department for molecular biomedical research,vlaams instituut voor biotechnologie,ghent,belgium,department of pulmonary medicine,erasmus university medical center,rotterdam, Netherlands, molecular immunology and signal transduction,max planck institute of biochemistry,martinsried, Germany
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Authors
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