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The Kinase Regulator Mob1 Acts as a Patterning Protein for Stentor Morphogenesis
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نویسنده
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slabodnick m.m. ,ruby j.g. ,dunn j.g. ,feldman j.l. ,derisi j.l. ,marshall w.f.
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منبع
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plos biology - 2014 - دوره : 12 - شماره : 5
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چکیده
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Morphogenesis and pattern formation are vital processes in any organism,whether unicellular or multicellular. but in contrast to the developmental biology of plants and animals,the principles of morphogenesis and pattern formation in single cells remain largely unknown. although all cells develop patterns,they are most obvious in ciliates; hence,we have turned to a classical unicellular model system,the giant ciliate stentor coeruleus. here we show that the rna interference (rnai) machinery is conserved in stentor. using rnai,we identify the kinase coactivator mob1-with conserved functions in cell division and morphogenesis from plants to humans-as an asymmetrically localized patterning protein required for global patterning during development and regeneration in stentor. our studies reopen the door for stentor as a model regeneration system. © 2014 slabodnick et al.
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آدرس
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department of biochemistry and biophysics,university of california,san francisco,ca, United States, department of biochemistry and biophysics,university of california,san francisco,ca, United States, department of biochemistry and biophysics,university of california,san francisco,ca, United States, department of biochemistry and biophysics,university of california,san francisco,ca,united states,department of biology,stanford university,palo alto,ca, United States, department of biochemistry and biophysics,university of california,san francisco,ca, United States, department of biochemistry and biophysics,university of california,san francisco,ca, United States
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Authors
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