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Finding Our Way through Phenotypes
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نویسنده
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deans a.r. ,lewis s.e. ,huala e. ,anzaldo s.s. ,ashburner m. ,balhoff j.p. ,blackburn d.c. ,blake j.a. ,burleigh j.g. ,chanet b. ,cooper l.d. ,courtot m. ,csösz s. ,cui h. ,dahdul w. ,das s. ,dececchi t.a. ,dettai a. ,diogo r. ,druzinsky r.e. ,dumontier m. ,franz n.m. ,friedrich f. ,gkoutos g.v. ,haendel m. ,harmon l.j. ,hayamizu t.f. ,he y. ,hines h.m. ,ibrahim n. ,jackson l.m. ,jaiswal p. ,james-zorn c. ,köhler s. ,lecointre g. ,lapp h. ,lawrence c.j. ,le novère n. ,lundberg j.g. ,macklin j. ,mast a.r. ,midford p.e. ,mikó i. ,mungall c.j. ,oellrich a. ,osumi-sutherland d. ,parkinson h. ,ramírez m.j. ,richter s. ,robinson p.n. ,ruttenberg a. ,schulz k.s. ,segerdell e. ,seltmann k.c. ,sharkey m.j. ,smith a.d. ,smith b. ,specht c.d. ,squires r.b. ,thacker r.w. ,thessen a. ,fernandez-triana j. ,vihinen m. ,vize p.d. ,vogt l. ,wall c.e. ,walls r.l. ,westerfeld m. ,wharton r.a. ,wirkner c.s. ,woolley j.b. ,yoder m.j. ,zorn a.m. ,mabee p.
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منبع
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plos biology - 2015 - دوره : 13 - شماره : 1
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چکیده
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Despite a large and multifaceted effort to understand the vast landscape of phenotypic data,their current form inhibits productive data analysis. the lack of a community-wide,consensus-based,human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology,including genomics,systems biology,development,medicine,evolution,ecology,and systematics. here we survey the current phenomics landscape,including data resources and handling,and the progress that has been made to accurately capture relevant data descriptions for phenotypes. we present an example of the kind of integration across domains that computable phenotypes would enable,and we call upon the broader biology community,publishers,and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. © 2015 deans et al.
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آدرس
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department of entomology,pennsylvania state university,university park,pa, United States, genome division,lawrence berkeley national lab,berkeley,ca, United States, department of plant biology,carnegie institution for science,stanford,ca,united states,phoenix bioinformatics,palo alto,ca, United States, school of life sciences,arizona state university,tempe,az, United States, department of genetics,university of cambridge,cambridge, United Kingdom, national evolutionary synthesis center,durham,nc, United States, department of vertebrate zoology and anthropology,california academy of sciences,san francisco,ca, United States, the jackson laboratory,bar harbor,me, United States, department of biology,university of florida,gainesville,fl, United States, muséum national d'histoire naturelle,département systématique et evolution,paris, France, department of botany and plant pathology,oregon state university,corvallis,or, United States, molecular biology and biochemistry department,simon fraser university,burnaby,bc, Canada, mta-elte-mtm,ecology research group,pázmány péter sétány 1c,budapest, Hungary, school of information resources and library science,university of arizona,tucson,az, United States, department of biology,university of south dakota,vermillion,sd, United States, department of botany,university of delhi,delhi, India, department of biology,university of south dakota,vermillion,sd, United States, muséum national d'histoire naturelle,département systématique et evolution,paris, France, department of anatomy,howard university college of medicine,washington,dc, United States, department of oral biology,college of dentistry,university of illinois,chicago,il, United States, stanford center for biomedical informatics research,stanford,ca, United States, school of life sciences,arizona state university,tempe,az, United States, biocenter grindel and zoological museum,hamburg university,hamburg, Germany, department of computer science,aberystwyth university,aberystwyth,ceredigion, United Kingdom, department of medical informatics & epidemiology,oregon health & science university,portland,or, United States, department of biological sciences,university of idaho,moscow,id, United States, mouse genome informatics,the jackson laboratory,bar harbor,me, United States, unit for laboratory animal medicine,department of microbiology and immunology,center for computational medicine and bioinformatics,and comprehensive cancer center,university of michigan medical school,ann arbor,mi, United States, department of entomology,pennsylvania state university,university park,pa, United States, department of organismal biology and anatomy,university of chicago,chicago,il, United States, department of biology,university of south dakota,vermillion,sd, United States, department of botany and plant pathology,oregon state university,corvallis,or, United States, cincinnati children's hospital,division of developmental biology,cincinnati,oh, United States, institute for medical genetics and human genetics,charité-universitätsmedizin berlin,berlin, Germany, muséum national d'histoire naturelle,département systématique et evolution,paris, France, national evolutionary synthesis center,durham,nc, United States, department of genetics,development and cell biology and department of agronomy,iowa state university,ames,ia, United States, signalling isp,babraham institute,babraham,cambridgeshire, United Kingdom, department of ichthyology,the academy of natural sciences,philadelphia,pa, United States, eastern cereal and oilseed research centre,ottawa,on, Canada, department of biological science,florida state university,tallahassee,fl, United States, richmond,va, United States, department of entomology,pennsylvania state university,university park,pa, United States, genome division,lawrence berkeley national lab,berkeley,ca, United States, european molecular biology laboratory - european bioinformatics institute,wellcome trust genome campus,hinxton, United Kingdom, european molecular biology laboratory - european bioinformatics institute,wellcome trust genome campus,hinxton, United Kingdom, european molecular biology laboratory - european bioinformatics institute,wellcome trust genome campus,hinxton, United Kingdom, division of arachnology,museo argentino de ciencias naturales - conicet,buenos aires, Argentina, allgemeine & spezielle zoologie,institut für biowissenschaften,universität rostock,universitätsplatz 2,rostock, Germany, institut für medizinische genetik und humangenetik charité – universitätsmedizin berlin,berlin, Germany, school of dental medicine,university at buffalo,buffalo,ny, United States, smithsonian institution,national museum of natural history,washington,dc, United States, knight cancer institute,oregon health & science university,portland,or, United States, division of invertebrate zoology,american museum of natural history,new york,ny, United States, department of entomology,university of kentucky,lexington,ky, United States, department of biological sciences,northern arizona university,flagstaff,az, United States, department of philosophy,university at buffalo,buffalo,ny, United States, department of plant and microbial biology,integrative biology,and the university and jepson herbaria,university of california,berkeley,ca, United States, bioinformatics and computational biosciences branch,office of cyber infrastructure and computational biology,national institute of allergy and infectious diseases,national institutes of health,bethesda,md, United States, department of biology,university of alabama at birmingham,birmingham,al, United States, the data detektiv,1412 stearns hill road,waltham,ma, United States, canadian national collection of insects,ottawa,on, Canada, department of experimental medical science,lund university,lund, Sweden, department of biological sciences,university of calgary,calgary,ab, Canada, universität bonn,institut für evolutionsbiologie und ökologie,bonn, Germany, department of evolutionary anthropology,duke university,durham,nc, United States, iplant collaborative university of arizona,thomas j. keating bioresearch building,tucson,az, United States, institute of neuroscience,university of oregon,eugene,or, United States, department of entomology,texas a & m university,college,station,tx, United States, allgemeine & spezielle zoologie,institut für biowissenschaften,universität rostock,universitätsplatz 2,rostock, Germany, department of entomology,texas a & m university,college,station,tx, United States, illinois natural history survey,university of illinois,champaign,il, United States, cincinnati children's hospital,division of developmental biology,cincinnati,oh, United States, department of biology,university of south dakota,vermillion,sd, United States
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Authors
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