|
|
|
|
Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression
|
|
|
|
|
|
|
|
نویسنده
|
franco c.a. ,jones m.l. ,bernabeu m.o. ,geudens i. ,mathivet t. ,rosa a. ,lopes f.m. ,lima a.p. ,ragab a. ,collins r.t. ,phng l.-k. ,coveney p.v. ,gerhardt h.
|
|
منبع
|
plos biology - 2015 - دوره : 13 - شماره : 4
|
|
چکیده
|
Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. the cellular and molecular principles of vessel regression are poorly understood. here we show that regression is mediated by dynamic and polarized migration of endothelial cells,representing anastomosis in reverse. establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network,we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. we predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments. © 2015 franco et al.
|
|
|
|
|
آدرس
|
vascular biology laboratory,london research institute—cancer research uk,lincoln’s inn laboratories,london,united kingdom,instituto de medicina molecular,lisboa, Portugal, vascular biology laboratory,london research institute—cancer research uk,lincoln’s inn laboratories,london, United Kingdom, centre for computational science,department of chemistry,university college london,london,united kingdom,complex,university college london,physics building,london,united kingdom,usher institute of population health sciences and informatics,the university of edinburgh,no. 9 edinburgh bioquarter,edinburgh, United Kingdom, vascular patterning laboratory,vesalius research center,ku leuven,department of oncology,vib3,leuven, Belgium, vascular patterning laboratory,vesalius research center,ku leuven,department of oncology,vib3,leuven, Belgium, vascular biology laboratory,london research institute—cancer research uk,lincoln’s inn laboratories,london, United Kingdom, instituto de medicina molecular,lisboa, Portugal, instituto de medicina molecular,lisboa, Portugal, vascular biology laboratory,london research institute—cancer research uk,lincoln’s inn laboratories,london, United Kingdom, vascular biology laboratory,london research institute—cancer research uk,lincoln’s inn laboratories,london, United Kingdom, vascular patterning laboratory,vesalius research center,ku leuven,department of oncology,vib3,leuven, Belgium, complex,university college london,physics building,london, United Kingdom, vascular biology laboratory,london research institute—cancer research uk,lincoln’s inn laboratories,london,united kingdom,usher institute of population health sciences and informatics,the university of edinburgh,no. 9 edinburgh bioquarter,edinburgh, United Kingdom
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|