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Neural Substrates Related to Motor Memory with Multiple Timescales in Sensorimotor Adaptation
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نویسنده
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kim s. ,ogawa k. ,lv j. ,schweighofer n. ,imamizu h.
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منبع
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plos biology - 2015 - دوره : 13 - شماره : 12
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چکیده
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Recent computational and behavioral studies suggest that motor adaptation results from the update of multiple memories with different timescales. here,we designed a model-based functional magnetic resonance imaging (fmri) experiment in which subjects adapted to two opposing visuomotor rotations. a computational model of motor adaptation with multiple memories was fitted to the behavioral data to generate time-varying regressors of brain activity. we identified regional specificity to timescales: in particular,the activity in the inferior parietal region and in the anterior-medial cerebellum was associated with memories for intermediate and long timescales,respectively. a sparse singular value decomposition analysis of variability in specificities to timescales over the brain identified four components,two fast,one middle,and one slow,each associated with different brain networks. finally,a multivariate decoding analysis showed that activity patterns in the anterior-medial cerebellum progressively represented the two rotations. our results support the existence of brain regions associated with multiple timescales in adaptation and a role of the cerebellum in storing multiple internal models. © 2015 kim et al.
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آدرس
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neuroscience graduate program,university of southern california,los angeles,ca,united states,feinberg school of medicine,northwestern university,chicago,il, United States, cognitive mechanisms laboratories,advanced telecommunications research institute international,keihanna science city,kyoto,japan,department of psychology,graduate school of letters,hokkaido university,sapporo, Japan, data sciences and operations department,marshall school of business,university of southern california,los angeles,ca, United States, division of biokinesiology and physical therapy,university of southern california,los angeles,ca,united states,euromov,movement to health laboratory (m2h),université montpellier-1,montpellier, France, cognitive mechanisms laboratories,advanced telecommunications research institute international,keihanna science city,kyoto,japan,center for information and neural networks,national institute of information and communications technology and osaka university,suita,osaka,japan,department of psychology,graduate school of humanities and sociology,the university of tokyo,tokyo, Japan
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Authors
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