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ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis
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نویسنده
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nagawa s. ,xu t. ,lin d. ,dhonukshe p. ,zhang x. ,friml j. ,scheres b. ,fu y. ,yang z.
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منبع
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plos biology - 2012 - دوره : 10 - شماره : 4
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چکیده
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Cell polarization via asymmetrical distribution of structures or molecules is essential for diverse cellular functions and development of organisms,but how polarity is developmentally controlled has been poorly understood. in plants,the asymmetrical distribution of the pin-formed (pin) proteins involved in the cellular efflux of the quintessential phytohormone auxin plays a central role in developmental patterning,morphogenesis,and differential growth. recently we showed that auxin promotes cell interdigitation by activating the rho family rop gtpases in leaf epidermal pavement cells. here we found that auxin activation of the rop2 signaling pathway regulates the asymmetric distribution of pin1 by inhibiting its endocytosis. rop2 inhibits pin1 endocytosis via the accumulation of cortical actin microfilaments induced by the rop2 effector protein ric4. our findings suggest a link between the developmental auxin signal and polar pin1 distribution via rho-dependent cytoskeletal reorganization and reveal the conservation of a design principle for cell polarization that is based on rho gtpase-mediated inhibition of endocytosis. © 2012 nagawa et al.
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آدرس
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center for plant cell biology,department of botany and plant sciences,university of california,riverside,ca, United States, center for plant cell biology,department of botany and plant sciences,university of california,riverside,ca,united states,temasek lifesciences laboratory ltd,national university of singapore, Singapore, center for plant cell biology,department of botany and plant sciences,university of california,riverside,ca,united states,state key laboratory of plant physiology and biochemistry,department of plant sciences,college of biological sciences,china agricultural university,beijing, China, department of biology,faculty of science,utrecht university,utrecht, Netherlands, state key laboratory of plant physiology and biochemistry,department of plant sciences,college of biological sciences,china agricultural university,beijing, China, department of plant systems biology,vib and department of plant biotechnology and genetics,ghent university,ghent, Belgium, department of biology,faculty of science,utrecht university,utrecht, Netherlands, state key laboratory of plant physiology and biochemistry,department of plant sciences,college of biological sciences,china agricultural university,beijing, China, center for plant cell biology,department of botany and plant sciences,university of california,riverside,ca, United States
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Authors
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