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Nonheritable cellular variability accelerates the evolutionary processes of cancer
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نویسنده
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frank s.a. ,rosner m.r.
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منبع
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plos biology - 2012 - دوره : 10 - شماره : 4
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چکیده
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Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. we discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. new approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy. © 2012 frank,rosner.
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آدرس
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department of ecology and evolutionary biology,university of california,irvine,ca,united states,department of ecology and evolution,university of chicago,chicago,il, United States, ben may department for cancer research,university of chicago,chicago,il, United States
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Authors
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