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Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication
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نویسنده
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frühbeis c. ,fröhlich d. ,kuo w.p. ,amphornrat j. ,thilemann s. ,saab a.s. ,kirchhoff f. ,möbius w. ,goebbels s. ,nave k.-a. ,schneider a. ,simons m. ,klugmann m. ,trotter j. ,krämer-albers e.-m.
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منبع
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plos biology - 2013 - دوره : 11 - شماره : 7
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چکیده
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Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination,but also for long-term survival of axons. degeneration of axons occurs in several human myelin diseases,however the molecular mechanisms of axon-glia communication maintaining axon integrity are poorly understood. here,we describe the signal-mediated transfer of exosomes from oligodendrocytes to neurons. these endosome-derived vesicles are secreted by oligodendrocytes and carry specific protein and rna cargo. we show that activity-dependent release of the neurotransmitter glutamate triggers oligodendroglial exosome secretion mediated by ca2+ entry through oligodendroglial nmda and ampa receptors. in turn,neurons internalize the released exosomes by endocytosis. injection of oligodendroglia-derived exosomes into the mouse brain results in functional retrieval of exosome cargo in neurons. supply of cultured neurons with oligodendroglial exosomes improves neuronal viability under conditions of cell stress. these findings indicate that oligodendroglial exosomes participate in a novel mode of bidirectional neuron-glia communication contributing to neuronal integrity. © 2013 frühbeis et al.
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آدرس
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department of molecular cell biology,university of mainz,mainz, Germany, department of molecular cell biology,university of mainz,mainz, Germany, department of molecular cell biology,university of mainz,mainz,germany,focus program translational neuroscience,university of mainz,mainz, Germany, department of molecular cell biology,university of mainz,mainz, Germany, department of molecular cell biology,university of mainz,mainz, Germany, max planck institute of experimental medicine,göttingen,germany,department of molecular physiology,university of saarland,homburg, Germany, max planck institute of experimental medicine,göttingen,germany,department of molecular physiology,university of saarland,homburg, Germany, max planck institute of experimental medicine,göttingen, Germany, max planck institute of experimental medicine,göttingen, Germany, max planck institute of experimental medicine,göttingen, Germany, dep. of psychiatry and psychotherapy,univ. of gottingen,german cnter for neurodegenerative dis.,dzne goettingen,cluster of excellence nanoscale microscopy and molecular physiol. of the brain (ex,dfg research center of molecular physiology of the brain,göttingen, Germany, max planck institute of experimental medicine,göttingen,germany,department of neurology,university of göttingen,göttingen, Germany, translational neuroscience facility,department of physiology,school of medical sciences,university of new south wales,sydney, Australia, department of molecular cell biology,university of mainz,mainz,germany,focus program translational neuroscience,university of mainz,mainz, Germany, department of molecular cell biology,university of mainz,mainz,germany,focus program translational neuroscience,university of mainz,mainz, Germany
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Authors
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