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Human mucosal associated invariant T cells detect bacterially infected cells
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نویسنده
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gold m.c. ,cerri s. ,smyk-pearson s. ,cansler m.e. ,vogt t.m. ,delepine j. ,winata e. ,swarbrick g.m. ,chua w.-j. ,yu y.y.l. ,lantz o. ,cook m.s. ,null m.d. ,jacoby d.b. ,harriff m.j. ,lewinsohn d.a. ,hansen t.h. ,lewinsohn d.m.
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منبع
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plos biology - 2010 - دوره : 8 - شماره : 6
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چکیده
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Control of infection with mycobacterium tuberculosis (mtb) requires th1-type immunity,of which cd8+ t cells play a unique role. high frequency mtb-reactive cd8+ t cells are present in both mtb-infected and uninfected humans. we show by limiting dilution analysis that nonclassically restricted cd8+ t cells are universally present,but predominate in mtbuninfected individuals. interestingly,these mtb-reactive cells expressed the va7.2 t-cell receptor (tcr),were restricted by the nonclassical mhc (hla-ib) molecule mr1,and were activated in a transporter associated with antigen processing and presentation (tap) independent manner. these properties are all characteristics of mucosal associated invariant t cells (mait),an innate t-cell population of previously unknown function. these mait cells also detect cells infected with other bacteria. direct ex vivo analysis demonstrates that mtb-reactive mait cells are decreased in peripheral blood mononuclear cells (pbmcs) from individuals with active tuberculosis,are enriched in human lung,and respond to mtb-infected mr1-expressing lung epithelial cells. overall,these findings suggest a generalized role for mait cells in the detection of bacterially infected cells,and potentially in the control of bacterial infection. © 2010 gold et al.
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آدرس
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division of pulmonary and critical care medicine,oregon health and science university,portland,or,united states,portland veterans administration medical center,portland,or, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or,united states,department of pediatrics,oregon health and science university,portland,or, United States, department of pediatrics,oregon health and science university,portland,or, United States, department of pediatrics,oregon health and science university,portland,or, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or,united states,portland veterans administration medical center,portland,or, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or,united states,portland veterans administration medical center,portland,or,united states,department of pediatrics,oregon health and science university,portland,or, United States, department of pathology and immunology,washington university school of medicine,st. louis,mo, United States, department of pathology and immunology,washington university school of medicine,st. louis,mo, United States, laboratoire d'immunologie et unité,inserm 932,institut curie paris, France, division of pulmonary and critical care medicine,oregon health and science university,portland,or,united states,department of pediatrics,oregon health and science university,portland,or, United States, department of pediatrics,oregon health and science university,portland,or, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or,united states,portland veterans administration medical center,portland,or, United States, department of pediatrics,oregon health and science university,portland,or,united states,department of molecular microbiology and immunology,oregon health and science university,portland,or, United States, department of pathology and immunology,washington university school of medicine,st. louis,mo, United States, division of pulmonary and critical care medicine,oregon health and science university,portland,or,united states,portland veterans administration medical center,portland,or,united states,department of molecular microbiology and immunology,oregon health and science university,portland,or, United States
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Authors
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