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A post-burst afterdepolarization is mediated by group I metabotropic glutamate receptor-dependent upregulation of Cav2.3 R-type calcium channels in CA1 pyramidal neurons
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نویسنده
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park j.-y. ,remy s. ,varela j. ,cooper d.c. ,chung s. ,kang h.-w. ,lee j.-h. ,spruston n.
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منبع
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plos biology - 2010 - دوره : 8 - شماره : 11
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چکیده
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Activation of group i metabotropic glutamate receptors (subtypes mglur1 and mglur5) regulates neural activity in a variety of ways. in ca1 pyramidal neurons,activation of group i mglurs eliminates the post-burst afterhyperpolarization (ahp) and produces an afterdepolarization (adp) in its place. here we show that upregulation of cav2.3 r-type calcium channels is responsible for a component of the adp lasting several hundred milliseconds. this medium-duration adp is rapidly and reversibly induced by activation of mglur5 and requires activation of phospholipase c (plc) and release of calcium from internal stores. effects of mglur activation on subthreshold membrane potential changes are negligible but are large following action potential firing. furthermore,the medium adp exhibits a biphasic activity dependence consisting of short-term facilitation and longer-term inhibition. these findings suggest that mglurs may dramatically alter the firing of ca1 pyramidal neurons via a complex,activity-dependent modulation of cav2.3 r-type channels that are activated during spiking at physiologically relevant rates and patterns. © 2010 park et al.
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آدرس
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department of neurobiology and physiology,northwestern university,evanston,il, United States, department of neurobiology and physiology,northwestern university,evanston,il,united states,department of epileptology,university of bonn,german research centre for neurodegenerative diseases (dzne),bonn, Germany, department of neurobiology and physiology,northwestern university,evanston,il,united states,department of psychology and neuroscience,university of colorado,boulder,co, United States, department of neurobiology and physiology,northwestern university,evanston,il,united states,department of psychology and neuroscience,university of colorado,boulder,co, United States, department of neurobiology and physiology,northwestern university,evanston,il,united states,department of physiology,sungkyunkwan university school of medicine,suwon, South Korea, department of life science,basic science institute for cell damage control,sogang university,seoul, South Korea, department of life science,basic science institute for cell damage control,sogang university,seoul, South Korea, department of neurobiology and physiology,northwestern university,evanston,il, United States
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Authors
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