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A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus
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نویسنده
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huang g.-j. ,smith a.l. ,gray d.h.d. ,cosgrove c. ,singer b.h. ,edwards a. ,sim s. ,parent j.m. ,johnsen a. ,mott r. ,mathis d. ,klenerman p. ,benoist c. ,flint j.
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منبع
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plos biology - 2010 - دوره : 8 - شماره : 12
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چکیده
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Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus,but its function remains unclear. measuring cellular proliferation in the hippocampus of 719 outbred heterogeneous stock mice revealed a highly significant correlation with the proportions of cd8+ versus cd4+ t lymphocyte subsets. this correlation reflected shared genetic loci,with the exception of the h-2ea locus that had a dominant influence on t cell subsets but no impact on neurogenesis. analysis of knockouts and repopulation of tcra-deficient mice by subsets of t cells confirmed the influence of t cells on adult neurogenesis,indicating that cd4+ t cells or subpopulations thereof mediate the effect. our results reveal an organismal impact,broader than hitherto suspected,of the natural genetic variation that controls t cell development and homeostasis. © 2010 huang et al.
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آدرس
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wellcome trust centre for human genetics,university of oxford,oxford, United Kingdom, department of zoology,university of oxford,oxford, United Kingdom, section on immunology and immunogenetics,joslin diabetes center and department of pathology,harvard medical school,boston,ma, United States, peter medawar building for pathogen research,nuffield department of medicine,university of oxford,oxford, United Kingdom, department of neurology,university of michigan,ann arbor,mi, United States, wellcome trust centre for human genetics,university of oxford,oxford, United Kingdom, peter medawar building for pathogen research,nuffield department of medicine,university of oxford,oxford, United Kingdom, department of neurology,university of michigan,ann arbor,mi, United States, section on immunology and immunogenetics,joslin diabetes center and department of pathology,harvard medical school,boston,ma, United States, wellcome trust centre for human genetics,university of oxford,oxford, United Kingdom, section on immunology and immunogenetics,joslin diabetes center and department of pathology,harvard medical school,boston,ma, United States, peter medawar building for pathogen research,nuffield department of medicine,university of oxford,oxford, United Kingdom, section on immunology and immunogenetics,joslin diabetes center and department of pathology,harvard medical school,boston,ma, United States, wellcome trust centre for human genetics,university of oxford,oxford, United Kingdom
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Authors
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