Therapeutic evaluation of anti-angiogenic and chemotherapy with or without Cox-2 inhibitor and immunomodulator drug in the management of canine mammary neoplasm

The present study was conducted for exploring the activity of anti-angiogenic and chemotherapeutic treatment with or without cox-2 inhibitor and immunomodulator drug in the management of spontaneous canine mammary neoplasms. antiangiogenic drug (tamoxifen) (n=10),chemotherapy (5-fu) (n=10),chemotherapy (5-fu) along with cox-2 inhibitor (etoricoxib) (n=10),chemotherapy (5-fu) along with cox-2 inhibitor (etoricoxib) and immunomodulator drug (levamisole) (n=10) were used in 40 female dogs having spontaneous mammary neoplasms. anticancer drug (5-fu) and anti-angiogenic drug (tamoxifen) induced apoptosis in canine mammary neoplasms. immunomodulator drug (levamisole) along with cox-2 inhibitor (etoricoxib) and chemotherapeutic drug (5-fluorouracil) induced significantly (p<0.01) higher apoptosis. in conclusion,chemotherapy with immunomodulator drug and cox-2 inhibitor was clinically proved better than chemotherapeutic agent (5-fu) alone in the treatment of canine mammary neoplasms. ©2015 pvj.