Tubulopapillary Adenocarcinoma of the Mammary Gland in an Amazon Jaguar (Panthera onca)

A 17-years-old, female amazon jaguar (panthera onca) was presented for a subcutaneous mass of the mammary gland. surgical excision and microscopic examination of the mass was performed. histopathologically, the mass was uncapsulated and composed of tubulopapillary lobules of atypical round to polygonal epithelial cells. tumor cells showed invasive growth into the connective tissue of the dermis and mitotic figures were frequently observed. tumor cells also showed diffusely strong positive for cytokeratin (ck) ae1/ae3, proliferation cell nuclear antigen (pcna) and ki-67 antibodies. but, ck14, vimentin and p63 immunoreactivity was mainly expressed in the myoepithelial cell layer. based on these pathological findings, present case was diagnosed as tubulopapillary adenocarcinoma of the mammary gland of amazon jaguar (panthera onca).