Interleukin 10 Suppresses the Function of Mouse Bone Marrow-Derived Dendritic Cells Infected with Classical Swine Fever Virus C-Strain

Interleukin (il)-10 inhibits the functions of antigen-presenting cells (apcs), including dendritic cells (dcs), however, the precise mechanism of action of il-10 has not been fully elucidated. in this work, the effects of il-10 on classical swine fever virus (csfv) c-strain-infected mouse bone marrow-derived immature dcs (bm-imdcs) were studied. additional il-10 suppressed the maturation of the infected bm-imdcs by down-regulating the expression levels of the surface molecules cd80, cd86 and major histocompatibility complex (mhc) classii, while the autocrine il-10 had no significant effect on the maturation status of the cells. both additional and autocrine il-10 markedly inhibited the secretion production of il-12p40 derived from the bm-imdcs infected with the c-strain, and reduced the capacity of dcs to promote allogeneic naive t cell proliferation. these results showed that il-10 may play an important role in the dcs-dependent immune response induced by csfv c-strain.