Anti-Diarrheal Effects of a Combination of Korean Traditional Herbal Extracts and Dioctahedral Smectite on Piglet Diarrhea Caused by Escherichia coli and Salmonella typhimurium

The present study evaluated anti-diarrheal effects of a mixture of coptidis rhizoma, lonicerae flos, and paeonia japonica (1:1:1, v/v/v) methanol extracts and dioctahedral smectite (clpd) on piglet diarrhea caused by escherichia coli (e. coli) and salmonella typhimurium (s. typhimurium). diarrhea index of group 1 administered by 0.5% clpd mixed with feed, decreased with the passage of time and was insignificantly differed compared to that of control. in group 2 administered by 1.0% clpd mixed with feed, diarrhea index was significantly decreased compared to that of control and group i during overall experimental periods (p<0.05). after administration of clpd mixed with feed, the number of e. coli and s. typhimurium in piglet feces of group 1 except for the 1st day was significantly decreased compared to that of the control group (p<0.05), and the number of e. coli and s. typhimurium in piglet feces of group 2 except for the 1st day was significantly decreased compared to that of the control group and group i (p<0.05). this study showed that clpd had anti-diarrheal effect on e. coli and s. typhimurium causing diarrhea in piglets. clpd could be an effective candidate for the treatment of enteric bacterial infections in piglets.