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Inhibition Effect of Alpha-Lipoic Acid on the Propagation of Influenza A Virus in MDCK Cells
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نویسنده
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Bai Si-Wei ,Chen Cui-Ying ,Ji Jun ,Xie Qing-Mei ,Ma Yun ,Sun Bao-Li ,Xue Chun-Yi ,Cao Yong-Chang ,Ma Jing-Yun ,Bi Ying-Zuo
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منبع
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pakistan veterinary journal - 2012 - دوره : 32 - شماره : 1 - صفحه:101 -106
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چکیده
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Influenza a viruses (iav) still pose a threat to animals and humans. currently, m2 protein ion channel inhibitors and neuraminidase inhibitors are the two main drugs for treating iav infections by interrupting virus assembly or release respectively, but the emergence of viral resistance was a concern for their long term uses. in this study, the inhibition effect of alpha-lipoic acid (α-la) on iav propagation has been evaluated in vitro. the results showed that α-la inhibited iav replication in mdck cells at 2mm, and also reduced nucleus translocation of nuclear factor κb (nf-κb) p65 at the concentration above 1mm. additionally, it was found that caspase-3 activity was remarkably inhibited and type i interferons (ifns) were upregulated following α-la treatment. this study indicated that α-la might be a potential anti-influenza virus agent worthy of further investigations.
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کلیدواژه
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Alpha-lipoic acid (α-LA) ,Influenza A virus (IAV) ,Inhibition ,Propagation
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آدرس
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South China Agricultural University, College of Animal Science, China, South China Agricultural University, College of Animal Science, China, South China Agricultural University, College of Animal Science, China, South China Agricultural University, College of Animal Science, China, Sun Yat-Sen University, College of Life Sciences, State Key Laboratory of Biocontrol, China, South China Agricultural University, College of Animal Science, China, Sun Yat-Sen University, College of Life Sciences, State Key Laboratory of Biocontrol, China, Sun Yat-Sen University, College of Life Sciences, State Key Laboratory of Biocontrol, China, South China Agricultural University, College of Animal Science, China, South China Agricultural University, College of Animal Science, China
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Authors
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