Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus)

Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. the present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits. the rabbits (n = 70) were divided into seven groups including normal and diabetic control, the remaining were aqueous, aqueous:methanol (70:30), aqueous:methanol (50:50), aqueous: methanol (30:70), and methanol extracts given for 30 days. serum levels of triglycerides, total cholesterol, ldl-cholesterol, hdl-cholesterol, alt and ast were estimated by using commercially available kits. the oral administration of aqueous:methanol (70:30) extract of the dodonaea viscosa leaves significantly (p<0.01) decreased the raised parameters (triglyceride, total cholesterol and ldl-cholesterol) to normal values. but the extract has significantly increased hdl-cholesterol, alt and ast levels. for the aqueous:methanol (70:30) extract given animals, the average serum level of total cholesterol was 60.00±1.30 mg/dl, ldl-cholesterol was 92.80±2.29 mg/dl, hdl-cholesterol was 31.80±1.0 mg/dl and triglyceride was 15.40±0.75 mg/dl while the average serum levels of alt and ast were 45.60±3.08 and 27.20±1.36 iu/dl, respectively. it is concluded from the study that aqueous:methanolic (70:30) extract of dodonaea viscosa leaves exerts antihyperlipidemic and hepatoprotective effects in the alloxan-induced diabetic rabbits.