Gambogic acid inhibits Hsp90 expressions in thiram-induced tibial dyschondroplasia

Tibial dyschondroplasia (td) is an important leg problem in fast growing birds that disturbs the proximal tibial growth plate. a study was conducted to evaluate the effects of gambogic acid (ga) on hsp-90 expressions and antioxidant capability in thiram-induced td chicken. one hundred and fifty day-old commercial broiler chicks were distributed into three groups: control (a),thiram-induced (b) and ga treated (c). tibial bone samples were collected at day 7 & 14 to evaluate hsp-90 expressions and liver samples were procured at the end of experiment to determine the antioxidant enzymes. as compared to control,the results demonstrated that significant increased hsp-90 gene expressions (p<0.05) in thiram-induced td chicks on day 7 & 14 contributing to the progression of td while a decrease in antioxidant capacity of liver on day 14. on administering the ga,the hsp-90 expressions were down-regulated and restored the antioxidant capacity of liver significantly (p<0.05). in conclusion,the ga ameliorated the growth plate vascularization in td-afflicted chicks which provides a new clinical usage of this promising agent against td. © 2015 pvj.