Effect of cyclosporine in canine atopic dermatitis: Safety,clinical evaluation,and mechanism studies

Atopic dermatitis (ad) is very common and sometimes treatment would be n c tolerance and efficacy compared to steroids. this study aimed to investigate safety,thhee tr challenged in dogs. cyclosporine a (csa) has been used in canine ad for its his study aime efficacy,and mechanism of csa in canine ad. blood works and urinalysis for safety verification every 4 weeks and canine atopic dermatitis extent and severity index (cadesi)-03,pruritus,overall coat condition,and scaling scores for clinical evaluation of the atopic dogs (n=7) were performed by every 2 weeks for 8 weeks. in addition,systemic total ige,th1/th2 cytokines,mast cell,cd3-positive t cells in the skin biopsy samples were evaluated in atopic dogs by elisa,semi-quantative pcr. blood works and urinalysis every 4 weeks showed no remarkable. cadesi score reduced significantly (p=0.0034,paired t-test) after 8 weeks,pruritus and scaling scores were improved significantly over times compared to base line. but overall coat condition showed no significant changes. total serum ige showed reduction pattern after 8 weeks,but there was not significant compared to the base line. in mrna level,il-2 and tnf-α related to th1 and il-4 and il-10 related th2 cytokines showed suppressive tendencies,but no significant difference were remarked after 8 weeks in the skin tissue. in histopathology,the inflammatory changes and mast cell counts showed significantly improved after 8 weeks. in conclusion,csa has efficacy and safety in atopic dogs,suppression of th1 and th2 cytokines were suspected mechanism in this study. ©2015 pvj.