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metabolic strategies of melanoma cells: mechanisms, interactions with the tumor microenvironment, and therapeutic implications
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نویسنده
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fischer g.m. ,vashisht gopal y.n. ,mcquade j.l. ,peng w. ,deberardinis r.j. ,davies m.a.
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منبع
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pigment cell and melanoma research - 2018 - دوره : 31 - شماره : 1 - صفحه:11 -30
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چکیده
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Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a variety of fuels that facilitate tumor progression and metastasis. the significance of metabolism in melanoma is supported by growing evidence of impact on the efficacy of contemporary therapies for this disease. there are also data to support that the metabolic phenotypes of melanoma cells depend upon contributions from both intrinsic oncogenic pathways and extrinsic factors in the tumor microenvironment. this review summarizes current understanding of the metabolic processes that promote cutaneous melanoma tumorigenesis and progression, the regulation of cancer cell metabolism by the tumor microenvironment, and the impact of metabolic pathways on targeted and immune therapies.
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کلیدواژه
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glycolysis ,melanoma ,metabolism ,oxidative phosphorylation ,tumor microenvironment
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آدرس
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university of texas md anderson cancer center, department of cancer biology, department of melanoma medical oncology, department of translational molecular pathology, usa, the university of texas md anderson cancer center, department of melanoma medical oncology, department of translational molecular pathology, usa, the university of texas md anderson cancer center, department of melanoma medical oncology, usa, the university of texas md anderson cancer center, department of melanoma medical oncology, usa, university of texas southwestern medical center, children's research institute, howard hughes medical institute, department of pediatrics, usa, the university of texas md anderson cancer center, department of melanoma medical oncology, department of translational molecular pathology, department of systems biology, usa
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Authors
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