In Vitro comparison of sustained release hydroxypropylmethyl cellulose and lipid-based matrix systems of diltiazem HCl

A polyglycolised glyceride lipid carrier,gelucire 50/13 (g50/13) was used to develop sustained release capsules while high viscosity grade hpmc was used to form sustained release tablets of diltiazem hcl both hpmc and g50/13 based formulations prepared with increasing polymer to drug ratios showed a substantial decrease in drug release rate. however,g50/13 based matrix containing stearyl alcohol caused greater retardation in release rate compared to g50/13 and provided more linear release profile which was chosen for comparison with hpmc based tablets the drug release from chosen formula of gelucire was stable at ambient temperature (25 °c) after aging for six months and essentially independent of ph. moreover,drug release rate of both sustained release tablets and capsules were found to be comparable with reference product,herbesser sr. copyright 2010 zoological society of pakistan.