Prevalence of multiple drug resistant escherichia coli in patients of urinary tract infection registering at a diagnostic laboratory in Lahore,Pakistan

The prevalence and antibiotic susceptibility pattern of e. coli was analyzed in urine samples of patients with acute and recurrent urinary tract infection visiting a diagnostic laboratory in lahore. the prevalence of mdr strains of e. coli among the isolates was also determined. a total of 310 isolates (73.1%) of e. coli were obtained from 424 positive culture isolates. the highest percentage of the isolates was present in the age group of 51- 75 years in both males and females (30.9% and 9.6% respectively). females were more frequently affected (77.4%) as compared to males (22.5%,p < 0.02). e. coli showed highest sensitivity towards imipenem (100%),meropenem (99.3%),piperacillin/tazobactum (96.8%),amikacin (89.7%),cefoperazone/sulbactum (86.8%),ceftazidime (77.2%),gentamicin (73.2%),and aztreonam (67.1%). 65.5% of isolates were resistant to more than 8 drugs,belonging to 3 or more than 3 different classes of drugs. copyright 2012 zoological society of pakistan.