Circulatory proteins in women with breast cancer and their chemotherapeutic responses

Study concerns the analysis of serum total proteins and fractions (albumin,total globulins,gamma and non-gamma globulins) of breast cancer patients following chemotherapy (fac regimen). for this purpose,blood samples of 84 breast cancer patients were collected from institute of nuclear medicine and oncology,lahore (inmol) before and after chemotherapy. these were compared with 52 age and sex matched healthy volunteers. analysis of serum total proteins and fractions were carried out using commercially available kits by semi-automated clinical chemistry analyzer. results were analyzed,statistically,using one-way analysis of variance and tukey's post hoc multiple comparison test. serum total proteins have shown a non-significant increase in patients when compared with controls. a remarkable reduction in serum albumin level (p<0.0001) was observed in newly diagnosed patients with a non-significant recovery of this protein following chemotherapy. comparatively,serum total globulins,gamma globulins and non-gamma globulins levels have shown significant increase (p<0.0001,p=0.0104 and p<0.0001,respectively) in newly diagnosed patients showing a non-significant recovery following chemotherapy. menopausal status and surgery did not show any role in changing serum protein profiles. our results provide preliminary information about total serum proteins and fractions of breast cancer patients indicating lowered serum albumin and higher serum globulins to compensate albumin reduction,in patients. chemotherapy did not play a significant role in recovery of these proteins. copyright 2013 zoological society of pakistan.