The protective effect of vitamin C against toxicity induced by lead-acetate on liver and spleen in swiss albino mice

The present study was carried out to investigate the protective effect of vitamin c as antioxidant to reduce hepatotoxicity and spleen toxicity induced by lead. lead acetate administered at 20 mg/kg intake caused severe alterations in liver and spleen manifested by hepatocytes degeneration and leucocytes infiltration and fibrosis in liver,ill-defined architecture and large macrophages in the spleen. vitamin c administered at 500 mg/kg of vitamin c one hour prior to lead reduced hepatotoxicity but did not affect liver fibrosis. moreover,vitamin c reduced the toxicity in spleen characterized by well-defined spleen architecture. © 2014 zoological society of pakistan.