GABAB receptor antagonist (CGP 55845) can be intraperitoneally supplemented as it does not affect the hematological and serum biochemical profile in adult female albino mice

Gabab receptor antagonists are known as memory enhancers in mammalian central nervous system. present study was designed to demonstrate the effect of intraperitoneal injection of gabab receptor antagonist,cgp 55845 [3-n [1-(s)-(3,4-dichlorophenyl) ethyl] amino-2-(s)-hydroxypropyl-p-benzyl-phosphinic acid],on the hematological and serum biochemical profile of adult female albino mice. female albino mice (13 week old) were either injected with 1mg/kg body weight/ml solvent of cgp 55845 (n=11) or saline solution (n=11) for 12 days. blood was collected directly from cardiac puncture and various hematological (blood glucose,mean corpuscular volume,packed cell volume,total red and white blood cell count) and serum biochemical parameters (cholesterol,aspartate transaminase,alanine transaminase,high density lipoprotein,low density lipoprotein,total protein and triglycerides) were determined for both treatments. our results indicated that total white blood cells (p = 0.1) had lower while total red blood cells (p = 0.67),packed cell volume (p = 0.36),glucose (p = 0.43) and mcv (p = 0.88) had higher values in cgp 55845 treated animals than in controls but the difference did not reached the statistical significance. data analysis for studied serum biochemical parameters indicated that total protein (p = 0.17),triglycerides (p = 0.76),cholesterol (p = 0.19) and alat (p = 076) had higher values in cgp 55845 treated female albino mice than control group while asat (p = 0.78) and ldl (p = 0.31) were higher in control as compared to cgp 55845 treated mice but again none of the value varied significantly when compared between two treatments indicating that it is safe to inject cgp 55845 intraperitoneally to treat the neurological ailments as it do not affect the blood chemistry. copyright 2015 zoological society of pakistan.