Pesticide-contaminated feeds in rainbow trout (Onchorhyncus mykiss W. 1792) aquaculture: Oxidative stress and DNA damage

Although chlorpyrifos (cpf) is an organophosphate medium-toxicity pesticide,it is highly toxic to fish and aquatic animals. this study was conducted with young rainbow trouts (n=20) raised on twelve floating cages on the atatürk dam lake. the fish were divided into four groups and were fed no insecticide (control groups),0.02,0.04 and 0.08 mg/l cfp-contaminated feed orally for 30 days. the oxidative status of trout blood tissues and the comet assay was used to measure dna strand breaks in blood erythrocytes. no significant differences were observed at all the doses of cfp between the values of hematocrit levels and total antioxidant status. on the other hand,there was a significant correlation of increased cfp doses with leucocyte levels (p<0.05),total oxidant status (p<0.01),oxidative stress index (p<0.05) and dna damage (p<0.01). copyright 2015 zoological society of pakistan.