Prevalence of colorectal adenocarcinoma in northern regions of Pakistan: A cross sectional study

Crc is one of the leading malignancies worldwide but it shows significant international variations in its distribution. pakistan is a country with its own peculiar environment. according to an estimate,the incidence of cancer in pakistan is rising since its independence in 1947,particularly in northern province,khyber pakhtoonkhawa. the genetic set up and the effect of external factors in the people of northern pakistan,may not be the same like americans or europeans. relatively little information is available about different aspects of crc in pakistan. present study was aimed at determining the frequency and prevalence of crc in khyber pakhtoonkhawa. a total of 181 cases of colorectal adenocarcinoma (cra) who underwent intestinal resection were studied. sections from both tumor and normal intestine for control were prepared. among the samples,75% were males and 25% females with 15 to 90 years of age (mean age 54.68±16.89 years). higher average age was found to have high tendency to acquire colorectal adenocarcinoma and rectosigmoid was the most important site. tumors were mostly exophytic,moderately differentiated with majority showing no lymphovascular invasion. copyright 2016 zoological society of pakistan.