Amelioration of streptozotocin induced diabetes in rats by eco-friendly composite nano-cinnamon extract

The study includes eco-friendly synthesis and characterization of silver/gold composite nanocinammon particles and antidiabetic assessment of orally administered aqueous extracts of cinnamon (jf) and silver/gold nano-cinnamon (sg jf) in streptozotocin induced diabetic rats. the experimental groups (36 rats) were equally divided: a diabetic control group treated with metformin (standard drug),diabetic group treated with aqueous cinnamon extract,and diabetic group treated with silver/gold nanoparticles. the nano silver/gold cinnamon particles were characterized. the body weight and blood glucose levels were estimated. nanoparticles characterization employed zetasizer,scanning electron microscopy,and transmission electron microscopy. the size and shape of the sg jf were 45.34 nm,stable,homogenous and showed mono dispersity distribution. the morphology of sg jf was highly variable with variety of shapes,following various arrangements. body weights of rats treated with cinnamon vs nano-cinnamon showed no significant change. however,jf and sg jf showed a significant decrease in body weights as compared to metformin. sg jf significantly decreased glucose levels among diabetic rats in comparison with the rats treated with metformin and control jf. similarly,metformin lowered glucose levels when compared to jf. thus,eco-friendly synthesized nano-cinnamon possesses a potent antihyperglycemic that ameliorated and improved insulin sensitivity and body weight.